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Cloettapreis_2013_Nr_41

29 Human behavioral/imaging genetic studies Animal behavioral & molecular studies Candidategene studies GWAS Human behavioral/imaging genetic studies Animal behavioral & molecular studies Candidategenee studies GWAS Figure 2. Crosstalk between behavioral/imaging genetic studies in humans, and behav­- ioral and molecular genetic studies in animals. Human candidate gene studies depend on preexisting information, which mostly origins from animal and molecular studies. ­Genome-wide association studies (GWAS) often identify genes, for which the function is not known or poorly understood. In such cases, behavioral and molecular genetic studies in animals may be useful to learn more about the causal role and the function of the gene. Taken from66 . ever simple or complicated they might be, successful gene identification stands and falls with independent replication of the gene-phenotype as- sociations. Secondly, given the correlative nature of behavioral genetic research, genetic findings must be corroborated through implementation of additional phenotypic assessment and methods. Whereas fMRI is cer- tainly a powerful tool to gain insight into the genetic differences in mem­

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