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Cloettapreis_2013_Nr_41

17 GENETICS OF HUMAN MEMORY: FROM GENE HUNTING TO DRUG DISCOVERY Andreas Papassotiropoulos and Dominique J.-F. de Quervain University Psychiatric Clinics, Transfaculty Research Platform, University of Basel, Switzerland Department of Psychology, Division of Molecular Neuroscience, University of Basel, Switzerland Department of Psychology, Division of Cognitive Neuroscience, University of Basel, Switzerland Department Biozentrum, Life Sciences Training Facility, University of Basel, Switzerland Abstract Memory is a fascinating capability that allows us to store and recall events that uniquely define our lives. Memory also allows us to learn from others – a prerequisite for the development and transmission of human cultures. The relevance of memory becomes evident in con- ditions where memory functions are disturbed as, for example, in ­dementia. Here we argue that the development and combination of high-throughput human genetic methods, of elaborated statistical approaches and of sophisticated methods to quantify memory at the neural systems level will facilitate the identification of novel ­memory-related genes in humans. Ultimately, a crosstalk between behavioral genetic studies and investigation of causality by molecu- lar genetic studies will pave the way towards the identification of ­biologically important molecules and the development of novel drugs.

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