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KEY PUBLICATIONS 1. Skoda, R.C., Seldin, D.C., Chiang, M., Peichel, C.L., Vogt, T.F., and Leder, P. (1993) Murine c-mpl, a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J., 12:2645–2653. 2. Skoda, R.C., Tsai, S.F., Orkin, S.H., and Leder, P. (1995) Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. J. Exp. Med., 181:1603–1613. 3. Stoffel, R., Wiestner, A., and Skoda, R.C. (1996) Thrombopoietin in thrombocyto- penic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood, 87:567–573. 4. Ghilardi, N., Ziegler, S., Wiestner, A., Stoffel, R., Heim, M.H., and Skoda, R.C. (1996) Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA, 93:6231–6235. 5. Wiestner, A. Schlemper, R.J. van der Maas, A.P.C., and Skoda, R.C. (1998) An acti- vating splice donor mutation in the thrombopoietin gene causes hereditary thrombocy- themia. Nature Genetics, 18:49–52. 6. Stoffel, R., Ziegler, S., Ghilardi, N., Ledermann, B., de Sauvage, F.J., and Skoda, R.C. (1999) Permissive role of mpl and G-CSF-receptors in hematopoietic cell fate deci- sions in vivo. Proc. Natl. Acad. Sci. USA, 96:698–702. 7. Kralovics, R., Buser, A.S., Teo, S.S., Coers, J., Tichelli, A. van der Maas, A.P.C., Skoda, R.C. (2003) Comparison of molecular markers in a cohort of patients with mye- loproliferative disease. Blood, 102:1869–1871. 8. Schomber, T., Kalberer, C., Wodnar-Filipowicz, A., Skoda, R.C. (2004) Gene silencing by lentivirus-mediated delivery of siRNA in human CD34+ cells Blood, 103:4511–4513. 9. Coers, J., Ranft, C., and Skoda, R.C. (2004) A truncated isoform of c-mpl with an essential C-terminal peptide targets the full-length receptor for degradation. J. Biol. Chem. 279:36397–36404. 39